Injectable chitosan- Ulva lactuca polysaccharide hydrogel neutralizes oxidative stress in experimental diabetic neuropathy

Polysaccharide –based hydro gels from marine algae are attractive materials for biomedical applications which include polyfunctionality and biodegradability. There were reports of many based hydrogels their in diabetic neuropathy. The present study aims to investigate the progressive effects injectable Chitosan-Ulva lactuca polysaccharide hydrogel (C-UL hydrogel) on experimentally induced neuropathy mice. Physicochemical properties C-UL analyzed by proximate composition, FTIR, SEM, swelling properties. Diabetes was a single intraperitoneal injection streptozotocin (STZ, 60 mg/kg). treatment started 15 days after diabetes induction continued 30 days. Serum levels cholesterol profile insulin assessed. In liver, brain, pancreas tissues, antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) measured. brain attenuated diabetes-induced changes serum excluding insulin. Diabetes-induced dysregulated SOD, CAT, GST ameliorated hydrogel. Histopathological analysis shows that corrects altered neuronal animals. prevents damage regulating antioxidant pathways mice model.